NEUROPHARMACOLOGICAL STUDIES ON A NEW SERIES OF ERGOT ALKALOIDS
نویسندگان
چکیده
منابع مشابه
Analysis of Ergot Alkaloids
The principles and application of established and newer methods for the quantitative and semi-quantitative determination of ergot alkaloids in food, feed, plant materials and animal tissues are reviewed. The techniques of sampling, extraction, clean-up, detection, quantification and validation are described. The major procedures for ergot alkaloid analysis comprise liquid chromatography with ta...
متن کاملHistorical View on Ergot Alkaloids
A short survey of the history of ergot, of the original and, for a long time, only source of ergot alkaloids, is given. Once a dreaded poison, ergot has changed its role over the centuries to become a rich treasure house of valuable pharmaceuticals. In the Middle Ages it was the cause of epidemics of ergotism, which cost tens of thousands of people their lives. Ergot was first mentioned by the ...
متن کاملBiosynthetic Pathways of Ergot Alkaloids
Ergot alkaloids are nitrogen-containing natural products belonging to indole alkaloids. The best known producers are fungi of the phylum Ascomycota, e.g., Claviceps, Epichloë, Penicillium and Aspergillus species. According to their structures, ergot alkaloids can be divided into three groups: clavines, lysergic acid amides and peptides (ergopeptines). All of them share the first biosynthetic st...
متن کاملScreening Isolates for Ergot Alkaloids
A procedure was developed to isolate and determine ergot alkaloid production by Acremonium coenophialum, the endophytic fungus of tall fescue. The procedure established that macerated leaf sheath or pith from inRorescence stem placed either in a liquid medium or on a corn meal-malt extract agar medium produced isolated mycelium and characteristic conidia within a 3to 3.5-week period. Once isola...
متن کاملErgot Alkaloids (Re)generate New Leads as Antiparasitics
Praziquantel (PZQ) is a key therapy for treatment of parasitic flatworm infections of humans and livestock, but the mechanism of action of this drug is unresolved. Resolving PZQ-engaged targets and effectors is important for identifying new druggable pathways that may yield novel antiparasitic agents. Here we use functional, genetic and pharmacological approaches to reveal that serotonergic sig...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1958
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65315-1